"Top 8 Ergonomic Mouse Choices for Ultimate Comfort in 2025"

It's 2025, and if you haven't figured out by now that ergonomic mice are the unsung heroes of your workspace, you’re probably still suffering from the dreaded "Mouse Arm" syndrome. Yep, it’s a thing. We've all been there, spending long hours slouched over a desk, hunched like Gollum over spreadsheets, only to be greeted by a world of wrist pain. Well, fear no more! I’ve gone deep into the ergonomic rabbit hole to find you the top eight ergonomic mice that'll have your wrists throwing a little party by the end of this read. Spoiler alert: your wrists will thank you.

Now, you might think a mouse is just a mouse, but you’d be seriously underestimating how much these nifty gadgets have evolved. We're talking multi-device connectivity, adjustable DPI settings for those moments when you need to switch from spreadsheet wrangling to intense game mode, and enough buttons to pretty much launch a rocket (or, you know, open your email). Plus, each of these mice boasts something unique, whether it’s the sculpted vertical design or the promise of a quiet click (no more startling your work buddies with aggressive mouse-clicking). So here’s my rundown of the top ergonomic mouse choices for 2025.

1. Anker 2.4G Wireless Vertical Ergonomic Optical Mouse For Work, Multi-Device Connectivity, 800 / 1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC - Black

Starting with the Anker 2.4G Wireless Vertical Ergonomic Optical Mouse. This mouse is like the cool kid in school who can do it all. It's got that trendy vertical design that’s not just for looks—it genuinely feels like a handshake every time you grab it. With the multi-device connectivity, you can switch between your laptop, desktop, and even your neighbor’s PC if you’re feeling adventurous. Toss in three DPI settings, and you’ve got yourself a mouse that adapts to whatever mood you’re in—from laid-back browsing to intense spreadsheet acrobatics.

2. TECKNET Ergonomic Mouse, Wireless Bluetooth Vertical Mouse, 4800 DPI Optical Tracking, 6 Adjustable DPI, Quiet Clicks, 2.4GHz with USB A Receiver, 6 Buttons, Wide Compatibility - Black

Enter the TECKNET Ergonomic Mouse, a wireless Bluetooth marvel that promises not just comfort but the joy of quiet clicks. Yes, quiet! Those who've never heard this blessing might scoff, but no one at home or in a study zone wants to hear your frantic clicks per minute. The 4800 DPI optical tracking ensures precision, and the six adjustable DPI settings mean it’s like having a Swiss Army knife in your palm. Plus, it’s compatible with nearly everything short of your toaster.

3. MEETION Ergonomic Mouse, Wireless Bluetooth Vertical Mouse with 3 Multi-Device for Bluetooth(5.3*2) & USB-A to USB-C Adapter, 4 DPI 1200-3200 Ergo Mice for Mac/Windows/PC/Laptop/Computer(Large Hands)

Moving on to the MEETION Ergonomic Mouse, which is clearly designed with giants in mind—yes, I mean those of you with large hands. This model boasts a Bluetooth capability with multi-device support and an additional USB-A to USB-C adapter, making it as versatile as they come. The four DPI options, ranging from 1200 to 3200, ensure that whether you’re designing graphics or managing spreadsheets, this mouse adjusts as quickly as you do.

4. Amazon Basics Computer Mouse Wireless, Ergonomic, 2.4 GHz Optical, DPI Adjustable, Compatible With PC, Mac, Laptop, Black

Then we have the Amazon Basics Computer Mouse, which proves yet again that basic doesn't mean boring. It might not have all the bells and whistles of its competitors, but its ergonomic design and DPI adjustability make it a solid, reliable choice. For those who want simplicity without compromising comfort, this mouse serves up ease of use without the overwrought features you might never touch.

5. Anker Ergonomic Optical USB Wired Vertical Mouse 1000/1600 DPI, 5 Buttons CE100

Featuring the Anker Ergonomic Optical USB Wired Vertical Mouse, designed for those who prefer their dependency on wires over the variable whims of Bluetooth. With its ergonomic grip, this mouse aims to reduce strain while still providing the precision you need with its 1000/1600 DPI settings. Ideal for work warriors who prefer the certainty of a cable connection, plus a few extra buttons for customizable shortcuts.

And yeah, I've thrown in a couple of curveballs. Because who doesn’t love a good wildcard?

6. Everlasting Comfort Cool Mist Humidifiers for Bedroom 6L - Humidifier Large Room No-Filter, Quiet Air Humidifier for Plants, Baby, Allergies, Dry Skin, Congestion, 50 Hr Run Time, Easy Clean

The Everlasting Comfort Cool Mist Humidifier sneaks into this list, just because you shouldn’t underestimate how a comfortable breathing environment can enhance your work life. No more dry skin or allergy flare-ups—this 6L beast runs for up to 50 hours, keeping your space humidified like a lush rainforest.

7. GHome Smart Plug Power Strip, 3 USB (30W Fast Charging) and 6 Individually Controlled Outlets, WiFi Surge Protector Works with Alexa & Google Home, Energy Monitor, 7.18 ft Mountable Flat Plug, 2A1C

The GHome Smart Plug Power Strip is not your ordinary power strip. This one comes equipped with three fast-charging USB ports and six outlets, all individually controlled via WiFi. This means you can Alexa your way through a power crisis, ensuring all gadgets under your command are juiced up and ready for action.

8. ZigBee Power Strips Surge Protector, USB C Power Strip 20W, Tuya/Smart Life APP/Timer, 4 Individually Controlled Outlets, Compatible with Alexa Google Home Phillilps HUE, Need ZigBee Gateway Hub

Finally, there's the ZigBee Power Strips Surge Protector, perfect for those who’ve invested heavily in smart home ecosystems. With compatibility for ZigBee Gateway Hub, this technologically advanced unit offers individually controlled outlets and a USB-C power, making it as smart as it is practical.

So, there you have it. A mix of mice and a sprinkle of tech-savvy gadgets to transform your workspace from merely functional to gloriously ergonomic and efficient.